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Factor XIIIa is used as a marker for fibro-histiocytic proliferations, dermal dendritic cells and to differentiate dermatofibroma from dermatofibrosarcoma. FACTOR XIIIA POSITIVE DERMAL DENDROCYTES IN AMERICAN TEGUMENTARY LEISHMANIASIS CUTANEOUS TISSUE RESPONSE The role of Langerhans cells in the pathogenesis of skin infectious diseases is well studied, however, there are few papers addressing factor XIIIa positive dermal dendrocytes (FXIIIa+DD) involvement in such processes. Conclusion: Factor-XIIIa-positive dendrocytes probably play a role in the regulation of the connective tissue remodeling that may accompany epidermal destruction. Background: Lymphocyte-poor graft-versus-host-reaction (GVHR) and toxic epidermal necrolysis (TEN) share some histological resemblance. Factor XIIIa positive cells in granulomatous lymph node lesions Factor XIIIa positive cells in granulomatous lymph node lesions Cotton, D.W.K.; Stephenson, T.J.; Hird, P.M. 1990-05-01 00:00:00 Sir: In the recent review (Goudie 1989) of Histological Typing of Thyroid Turnours (Hedinger, Williams & Sobin 1988), attention was drawn to the limited discussion and absence of references in this book DOI: 10.1097/00000372-199810000-00022 Corpus ID: 11184222. CD34 and factor XIIIa-positive microvascular dendritic cells and the family of fibrohistiocytic mesenchymal tumors.
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Immunohistochemical analysis showed that factor XIIIa-positive histiocytic cells were distributed in the area without haemosiderin, but such cells were absent in the area with its deposition. Factor XIIIa-positive dermal dendritic cells and HLA-DR expression in radial versus vertical growth-phase melanomas. Fullen DR(1), Headington JT. Author information: (1)Department of Pathology, University of Michigan Hospitals, Ann Arbor, USA. Comment in J Cutan Pathol. 1999 May;26(5):263-4. Factor XIIIa Positive Control Slides suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections); find Sigma-Aldrich-251S MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Factor XIII or fibrin stabilizing factor is a zymogen found from the blood of humans and some other animals.
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Fullen DR(1), Headington JT. Author information: (1)Department of Pathology, University of Michigan Hospitals, Ann Arbor, USA. Comment in J Cutan Pathol. 1999 May;26(5):263-4.
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Factor XIIIA is the catalytic subunit and is a dimer of M.W. 160,000. According to studies, Factor XIII is present in plasma as an alpha2beta2 heterodimer (M.W.
Many of the spindle cells in patch- and plaque-stage lesions of KS, however, are negative for factor XIIIa. Factor XIII a-positive DD may be altered in some genetic disorders affecting the connective tissue structure [15,17,20–26]. There is ample evidence that many, if not all, of these disorders are associated with alterations in the tensile properties of the dermis. In addition, a link between Factor XIII a-positive DD and intratissular mechanical
Factor XIIIa positive dermal dendrocytes in American tegumentary leishmaniasis cutaneous tissue response .
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Factor XIIIa is more likely to be negative Tuberous xanthoma: Occurs in areas of pressure Associated with hypercholesterolemia and high LDL Consists of dermal aggregates of foam cells, no Touton cells or inflammatory cells Spitz nevus: Nests of spindle and epithelioid cells within a uniformly hyperplastic epidermis DFSP is diffusely CD34 positive and Factor XIIIa negative, whereas dermatofibromas (and additional fibrohistiocytic tumor types other than DFSP) show the converse of this profile or only limited CD34 reactivity at the advancing edge of the lesion. 402 At a molecular level, all forms of DFSP are characterized by a balanced translocation between the collagen type 1-alpha1 gene (COL1A1) and the platelet-derived growth factor-beta gene (PDGFB). Factor XIIIa (reportedly positive in neurofibroma but negative in schwannoma), and CD56 (reportedly nega-tive in neurofibroma and positive in schwannoma, although I have seen focal CD56 in a plexiform neurofi-broma). We have also evaluated neurofilament in a number of these types of cases, and I have observed neu- DF stains positively for Factor XIIIa and negative for CD34, while DFSP stains oppositely with positive CD34 staining and negative Factor XIIIa staining. This differentiation is, however, not absolute, as there are reports of Factor XIIIa positive DFSPs and of CD34 positive DFs. Factor XIII deficiency is an extremely rare inherited blood disorder characterized by abnormal blood clotting that may result in abnormal bleeding.
Factor XIIIa positive cells in granulomatous lymph node lesions Cotton, D.W.K.; Stephenson, T.J.; Hird, P.M. 1990-05-01 00:00:00 Sir: In the recent review (Goudie 1989) of Histological Typing of Thyroid Turnours (Hedinger, Williams & Sobin 1988), attention was drawn to the limited discussion and absence of references in this book as well as in the other volumes in the WHO series. Factor XIIIa positive cells in human skin represent a specific population of bone marrow dermal dendritic cells, distinct from Langerhans cells which share some features common to mononuclear phagocytes.
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av K Junkunlo · 2017 — tion to Drosophila, the freshwater crayfish also serves as a good model Then, TGase, a homologue for clotting factor XIIIa mediates the cross- rise to a clinical presentation similar to DVT or PE, resulting in a false positive diagnosis. 99mTc-NC100668 is a substrate for factor XIIIa and as a potential #ISTH2020 #FXIII #FactorXIII #FXIIIa #TECHNOFLUOR #CEVERON_s100. för 38 veckor sedan Good Morning ☀️ we are getting ready ! Happy to welcome av KR Wilting · Citerat av 58 — of tumour necrosis factor alpha (TNF-alpha), interleu- kin-6 and In addition to the S. Enteritidis PT 13a-positive Brand A spice mix from an av J Elf — products can serve as diagnostic markers of thrombin and / or Factor XIIIa plus plasmin positive DD results are usually not considered useful to “rule in” DVT. coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and providing a structured follow-up for children testing positive for the disease.
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The biodistribution of NC100668 and the effect of excess
Before you can use immunostains to help recognize different tumors and diseases in dermpath, you must first understand how they stain the normal structures i Factor Xiiia staining Four of 10 (40%) compound nevi, 9 of 20 (45%) radial growth-phase melanomas, and 12 of 20 (60%) vertical growth-phase melanomas showed an increase in factor Xllla staining of DDCs (Ta-ble 1). The majority of cases, with the exception of 3 vertical growth-phase melanomas, had only slight (1-I-) increased staining (Fig. 1 Dendritic, factor XIIIa positive cells were observed in all tissues studied, but were most numerous in skin and mucosal tissues (gastrointestinal tract, bladder).